hypergranulationn.
/ˌhʌɪpəɡranjᵿˈleɪʃn/, U.S. /ˌhaɪpərˌɡrænjəˈleɪʃ(ə)n/ Medicine.
1. The formation of excessive granulation tissue. Also: (more fully hypergranulation tissue) tissue of this nature (= proud flesh n.); a localized area of such tissue.
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1831 J. Burns Princ. Surg. I. 289 We may call this an overacting, a hypergranulating, or a fungous ulcer, as we please.]
1871 Brit. Med. Jrnl. 30 Dec. 757/2 In cases of open scrofulous glandular sores of the neck, with undermined edges or hypergranulation, he finds cauterisation with potassa fusa furnish the best results.
1898 Trans. State Med. Soc. Wisconsin 32 127 In case hypergranulation tissue is present it must be destroyed by caustics.
1959 Oral Surg., Oral Med., Oral Pathol. 12 909 A few months later hypergranulations formed mesial to the left canine.
1983 Biomaterials 4 319/1 Studies have shown these dressings also to be effective in the management of hypergranulation tissue.
2006 S. Bale & V. Jones Wound Care Nursing (ed. 2) 23 Epithelial migration cannot continue over hypergranulation and this tissue needs to be flattened to effect complete healing.
2. The presence of an unusually or abnormally large number of granules within a cell.
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1937 Jrnl. Industr. Hygiene & Toxicol. 19 297/1 The liver cells showed swelling, hypergranulation, hyaline inclusions and vacuolation.
1962 Lancet 30 June 1405/1 In kidneys of patients with this disorder studied by biopsy, hypertrophy, and hypergranulation of the J.G.A. [= juxtaglomerular apparatus] were observed.
2005 Leukemia Res. 29 1372/2 Eosinophilic dysplasia was defined by the presence of megaloblastoid features and abnormal basophilic and eosinophilic hypergranulation.
This is a new entry (OED Third Edition, June 2012; most recently modified version published online March 2022).
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