hydroxyprogesteronen.

/hʌɪˌdrɒksɪprəʊˈdʒɛstərəʊn/

Etymology: < hydroxy- comb. form + progesterone n.

Biochemistry and Pharmacology.

Any of several synthetic derivatives of progesterone that have a hydroxyl group in place of one of the hydrogen atoms of the steroid nucleus; esp. the derivative in which the hydroxyl group is at position 17, used (chiefly as the caproate ester) as a long-acting progestational compound in cases of corpus luteum deficiency.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun]

epinephrine1899

pituitrin1909

oxytocin1927

Pitocin1929

Pitressin1929

progestin1930

progesterone1935

methyltestosterone1936

pregnenolone1936

hexœstrol1939

stilboestrol1939

hydroxyprogesterone1941

progestogen1941

Premarin1942

hydroxycorticosterone1943

gestagen1948

hydrocortisone1951

cortisol1953

fluorohydrocortisone1954

isophane1954

prednisolone1955

prednisone1955

norethisterone1956

norethynodrel1957

dexamethasone1958

fludrocortisone1958

norethindrone1960

antidiuretic hormone1961

medroxyprogesterone1962

Pergonal1963

mesterolone1965

norgestrel1966

quinestrol1966

pancuronium1967

pentagastrin1967

levonorgestrel1977

1941 Jrnl. Biol. Chem. 139 855 It was found to be the hitherto unknown steroid..l7-hydroxyprogesterone.., a position isomer of desoxycorticosterone.

1948 W. H. Pearlman in G. Pincus & K. V. Thimann Hormones I. xi. 441 Erhart and co-workers..described the preparation of 12(α)-hydroxyprogesterone..from desoxycholic acid..; the substance was found to be lacking in physiological activity.

1954 Nature 30 Oct. 839/2 Various derivatives of progesterone by oxidation at C₁₁ such as..11-α-hydroxyprogesterone and 11-β-hydroxyprogesterone..have been found to be only about 3–10 per cent as progestational as progesterone.

1962 N. Applezweig Steroid Drugs v. 100 When administered to pregnant women for the prevention of habitual abortion, Norlutin and 17α-hydroxyprogesterone caproate have been shown on occasion to cause masculinization of the female fetus.

1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 93 The progestogen [in contraceptive pills] is either a 19-norsteroid derivative..or a 17-hydroxy-progesterone derivative.

This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2022).

单词	hydroxyprogesterone
释义	hydroxyprogesteronen. /hʌɪˌdrɒksɪprəʊˈdʒɛstərəʊn/ Etymology: < hydroxy- comb. form + progesterone n. Biochemistry and Pharmacology. Any of several synthetic derivatives of progesterone that have a hydroxyl group in place of one of the hydrogen atoms of the steroid nucleus; esp. the derivative in which the hydroxyl group is at position 17, used (chiefly as the caproate ester) as a long-acting progestational compound in cases of corpus luteum deficiency. ΘΚΠ the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun] epinephrine1899 pituitrin1909 oxytocin1927 Pitocin1929 Pitressin1929 progestin1930 progesterone1935 methyltestosterone1936 pregnenolone1936 hexœstrol1939 stilboestrol1939 hydroxyprogesterone1941 progestogen1941 Premarin1942 hydroxycorticosterone1943 gestagen1948 hydrocortisone1951 cortisol1953 fluorohydrocortisone1954 isophane1954 prednisolone1955 prednisone1955 norethisterone1956 norethynodrel1957 dexamethasone1958 fludrocortisone1958 norethindrone1960 antidiuretic hormone1961 medroxyprogesterone1962 Pergonal1963 mesterolone1965 norgestrel1966 quinestrol1966 pancuronium1967 pentagastrin1967 levonorgestrel1977 1941 Jrnl. Biol. Chem. 139 855 It was found to be the hitherto unknown steroid..l7-hydroxyprogesterone.., a position isomer of desoxycorticosterone. 1948 W. H. Pearlman in G. Pincus & K. V. Thimann Hormones I. xi. 441 Erhart and co-workers..described the preparation of 12(α)-hydroxyprogesterone..from desoxycholic acid..; the substance was found to be lacking in physiological activity. 1954 Nature 30 Oct. 839/2 Various derivatives of progesterone by oxidation at C₁₁ such as..11-α-hydroxyprogesterone and 11-β-hydroxyprogesterone..have been found to be only about 3–10 per cent as progestational as progesterone. 1962 N. Applezweig Steroid Drugs v. 100 When administered to pregnant women for the prevention of habitual abortion, Norlutin and 17α-hydroxyprogesterone caproate have been shown on occasion to cause masculinization of the female fetus. 1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 93 The progestogen [in contraceptive pills] is either a 19-norsteroid derivative..or a 17-hydroxy-progesterone derivative. This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2022). < n.1941
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