apo-enzymen.

1936 Union Internat. de Chimie Compt. Rend. 43 Le complexe total sera appelé holoenzyme et le résidu, après séparation de ses activateurs, sera appelé apoenzyme.]

1936 Chem. Abstr. 6397 A comprehensive treatise discussing..character and action of coenzymes and apoenzymes.

1944 Jrnl. Pharm. & Exp. Therap. 81 246 This enzyme like substance appears to attack the apoenzyme or protein part of the oxidative enzyme system.

1950 Endeavour IX. 145/1 The entire enzyme or holoenzyme is built up of at least two fractions: (a) The apoenzyme, which is always a protein; it is colloidal and thermolabile. (b) The co-enzyme, of variable chemical constitution, frequently a phosphoric ester and sometimes a metallic derivative; very often the co-enzyme, which is non-colloidal, is fairly thermostable.

1961 A. S. MacNalty Brit. Med. Dict. 123/2 Apo-enzyme, the protein carrier, or enzyme proper (e.g. carboxylase) which, with a co-enzyme (co-carboxylase), carries out an enzymic reaction.