haptophoren.adj.

Brit.

/ˈhaptə(ʊ)fɔː/, U.S.

/ˈhæptəˌfɔr/

Forms: 1800s– haptophore, 1900s– haptophor.

Origin: A borrowing from German. Etymon: German haptophor.

Etymology: < German haptophor, adjective (P. Ehrlich 1898, in Deutsch. med. Wochenschr. 22 Sept. 599/2) < ancient Greek ἅπτειν to fasten (see haptic adj.) + German -o- -o- connective + -phor -phore comb. form.

Immunology and Pharmacology.

A. n.

A part of a molecule, esp. a toxin or drug molecule, which enables it to bind to a cell or to another substance; a binding site; a receptor. Now frequently historical with reference to the theories of Paul Ehrlich (see quot. 1899).

ΚΠ

1899 tr. P. Ehrlich in Trans. Jenner Inst. Prevent. Med. 2nd Ser. 11 I have already..touched upon the question whether..the toxin molecule contains two independent groups, of which the one (the toxophore) conditions the toxicity, and the other (the haptophore) the combining property.

1904 Brit. Med. Jrnl. 10 Sept. 574 Although the toxophoric group may be similar, the haptophor is dissimilar.

1960 New Biol. 31 104 It was very hard to conceive that ‘haptophores’ could pre-exist.

2009 A. E. Frankel et al. in R. K. Oldham & R. O. Dillman Princ. Cancer Biotherapy (ed. 5) xi. 426/2 The molecules are homogeneous with a single site of linkage between the haptophore and toxophore.

B. adj. (attributive).

Of the nature of a haptophore; haptophoric. Now chiefly historical with reference to the theories of Paul Ehrlich.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > immunogen or antigen > [adjective] > immunization theory: groups of atoms

haptophorous1898

haptophore1899

haptophoric1900

zymophore1900

zymophoric1902

1899 tr. P. Ehrlich in Trans. Jenner Inst. Prevent. Med. 2nd Ser. 12 With the help of the haptophore groups, the toxin molecule becomes ‘anchored’ to the cell.

1910 Lancet 18 June 1670/1 When a toxin is brought into contact with its antitoxin no visible change is produced, but the combination is non-virulent, owing to the occupation of the haptophore group of the toxin, according to Ehrlich's hypothesis.

1955 H. Moriyama Immunity ii. i. 112 Heat and other agencies destroyed the agglutinophore and left the haptophore groups relatively unaltered.

2004 J. M. Cruse & R. E. Lewis Atlas Immunol. vii. 205/2 Ehrlich proposed a haptophore group that reacted with a corresponding group of an antigen.

This entry has been updated (OED Third Edition, December 2013; most recently modified version published online March 2022).

单词	haptophore
释义	haptophoren.adj. Brit. /ˈhaptə(ʊ)fɔː/, U.S. /ˈhæptəˌfɔr/ Forms: 1800s– haptophore, 1900s– haptophor. Origin: A borrowing from German. Etymon: German haptophor. Etymology: < German haptophor, adjective (P. Ehrlich 1898, in Deutsch. med. Wochenschr. 22 Sept. 599/2) < ancient Greek ἅπτειν to fasten (see haptic adj.) + German -o- -o- connective + -phor -phore comb. form. Immunology and Pharmacology. A. n. A part of a molecule, esp. a toxin or drug molecule, which enables it to bind to a cell or to another substance; a binding site; a receptor. Now frequently historical with reference to the theories of Paul Ehrlich (see quot. 1899). ΚΠ 1899 tr. P. Ehrlich in Trans. Jenner Inst. Prevent. Med. 2nd Ser. 11 I have already..touched upon the question whether..the toxin molecule contains two independent groups, of which the one (the toxophore) conditions the toxicity, and the other (the haptophore) the combining property. 1904 Brit. Med. Jrnl. 10 Sept. 574 Although the toxophoric group may be similar, the haptophor is dissimilar. 1960 New Biol. 31 104 It was very hard to conceive that ‘haptophores’ could pre-exist. 2009 A. E. Frankel et al. in R. K. Oldham & R. O. Dillman Princ. Cancer Biotherapy (ed. 5) xi. 426/2 The molecules are homogeneous with a single site of linkage between the haptophore and toxophore. B. adj. (attributive). Of the nature of a haptophore; haptophoric. Now chiefly historical with reference to the theories of Paul Ehrlich. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > immunogen or antigen > [adjective] > immunization theory: groups of atoms haptophorous1898 haptophore1899 haptophoric1900 zymophore1900 zymophoric1902 1899 tr. P. Ehrlich in Trans. Jenner Inst. Prevent. Med. 2nd Ser. 12 With the help of the haptophore groups, the toxin molecule becomes ‘anchored’ to the cell. 1910 Lancet 18 June 1670/1 When a toxin is brought into contact with its antitoxin no visible change is produced, but the combination is non-virulent, owing to the occupation of the haptophore group of the toxin, according to Ehrlich's hypothesis. 1955 H. Moriyama Immunity ii. i. 112 Heat and other agencies destroyed the agglutinophore and left the haptophore groups relatively unaltered. 2004 J. M. Cruse & R. E. Lewis Atlas Immunol. vii. 205/2 Ehrlich proposed a haptophore group that reacted with a corresponding group of an antigen. This entry has been updated (OED Third Edition, December 2013; most recently modified version published online March 2022). < n.adj.1899
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