ˌantiˈhistamineadj.n.
A. adj.
That counteracts the effect of histamine.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > antihistamine medicines > [adjective]
antihistamine1933
methapyrilene1949
1933 A. C. H. Yen & Hsi-Chun Chang in Proc. Soc. Exper. Biol. XXXI. 338 The sensitivity to histamine in guinea pig and man may be accounted for by the absence of antihistamine activity in their blood.
1942 Jrnl. Immunology 44 219 In a series of studies on the antihistamine activity of a number of derivatives of phenoxyethylamine..(1571 F) prevented certain histamine effects.
1947 Lancet 17 May 678/1 (title) The Anti-histamine Drugs.
B. n.
A synthetic drug having this property, used esp. in the treatment of certain allergic conditions.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > antihistamine medicines > [noun]
pyribenzamine1946
diphenhydramine1947
tripelennamine1947
mepyramine1949
anti-histaminic1950
meclozine1955
triprolidine1956
antihistamine1957
trimeprazine1959
methapyrilene1974
1957 N.Z. Listener 26 July 15/1 The antihistamines, discovered to have a quietening effect and to act specifically against motion sickness.
Derivatives
ˌanti-histaˈminic n.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > antihistamine medicines > [noun]
pyribenzamine1946
diphenhydramine1947
tripelennamine1947
mepyramine1949
anti-histaminic1950
meclozine1955
triprolidine1956
antihistamine1957
trimeprazine1959
methapyrilene1974
1950 Chem. & Engin. News 28 846/1 Opinion is divided on the use of antihistaminics as cold cures.
1955 Sci. News Let. 16 July 40/2 Many of the itch remedies used today..such as anti-histaminics..may depend for their results on a partial blocking of the proteinases, or itch enzymes.
ˌanti-histaˈminic adj.
ΚΠ
1964 S. Duke-Elder Parsons' Dis. Eye (ed. 14) xxii. 313 Treatment should consist of the administration of anti-histaminic or diuretic drugs in the early stages.
This entry has not yet been fully updated (first published 1972; most recently modified version published online November 2010).
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adj.n.1933