antigenn.
A foreign substance which, when introduced into a living organism, stimulates the production of an antibody.
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the world > life > biology > substance > process stimulators or inhibitors > immunogen or antigen > [noun]
antigen1908
isoantigen1936
rhesus antigen1946
immunogen1959
alloantigen1964
1908 Park & Bolduan in Nuttall & Graham-Smith Bacteriol. of Diphtheria 628, v. Pirquet and Schick attribute the immediate or hastened reaction and indeed the serum disease as a whole to an interaction between the antigen and the antibody.
1911 Jrnl. Chem. Soc. 100 ii. 812 When an optimum dose of antigen (goat's or rat's blood) is injected intravenously into a dog.
1955 Sci. News Let. 16 Apr. 253/1 The test reaction is based on the body's ability to react to and destroy bacteria and foreign protein invaders. These foreign agents are called antigens, while the body's own destructive agents are referred to as antibodies.
1959 Chambers's Encycl. VII. 398/1 Most antigens are proteins or contain substantial amounts of protein, and they have a high molecular weight.
Derivatives
antiˈgenic adj. of the nature of an antigen.
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the world > life > biology > substance > process stimulators or inhibitors > immunogen or antigen > [adjective]
antigenic1913
isoantigenic1938
alloantigenic1965
1913 Arch. Internal Med. XI. 85 The ‘antigenic’ function of all the extracts resides solely in the lipoid fraction.
1916 Olitsky & Bernstein in Jrnl. Infectious Diseases XIX. 259 We have shown that organisms grown on serum media incorporate..those serum elements which possess serum antigenic properties.
antiˈgenically adv.
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1946 Nature 27 July 120/1 The hæmagglutinins are complexes of a phospholipid (probably lecithin) with an antigenically specific virus constituent.
ˌantigeˈnicity n. the condition or property of being antigenic.
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1946 Nature 17 Aug. 239/1 The loss in antigenicity during preparation of the toxoid (measured by flocculation) was about half that usually found.
Draft additions January 2002
antigen-presenting cell n. Immunol. any cell that assists in the production of immune responses by presenting antigen (see present v.); esp. any of several types of cell with monocytic lineage that present antigen in association with class II MHC molecules, to helper T lymphocytes.
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1975 Proc. National Acad. Sci. U.S.A. 72 5098/2 It may therefore be that..interaction between sensitized lymphocytes and antigen-presenting cells leads to the generation of suppressive influences which prevent the DTH response.
1985 Sci. Amer. June 40/1 They set out to show that Langerhans cells synthesize interleukin-1 (IL-1), a factor known to be secreted by other antigen-presenting cells, the macrophages.
2000 Brit. Med. Jrnl. (Electronic ed.) 9 Dec. 1430 [Statins] do this by blocking the ability of interferon gamma, a cytokine, which activates antigen presenting cells, to express MHC-II on their surface.
This entry has not yet been fully updated (first published 1933; most recently modified version published online June 2011).
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n.1908