单词 | genomic footprinting |
释义 | > as lemmasgenomic footprinting 2. Molecular Biology. More fully DNA footprinting, DNase footprinting, genomic footprinting. Any of various techniques used to determine the sites at which proteins bind to DNA or RNA, employed esp. in the study of gene expression and regulation. Frequently attributive. Cf. footprint n. 7. ΚΠ 1978 D. Galas & A. Schmitz in Nucleic Acids Res. 5 3157 (title) DNAase footprinting: a simple method for the detection of protein-DNA binding specificity. 1987 Science 5 June 1241/2 Genomic footprinting experiments with the putative glucocorticoid response element of the tyrosine transaminase gene reveal only minor differences in the presence and absence of hormone. 1992 Sci. News 23 May 340/1 Stillman used a technique called DNA ‘footprinting’ to track down the new proteins. 2005 H. I. Swanson et al. in L. H. Lash Drug Metabolism & Transport ii. 29 Footprinting analysis uses a DNA fragment that is radiolabeled at one end and is allowed to equilibrate with the DNA binding proteins (typically present in a nuclear extract). < as lemmas |
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