gangliosiden.

Brit.

/ˈɡaŋɡlɪə(ʊ)sʌɪd/, U.S.

/ˈɡæŋɡliəˌsaɪd/

Origin: Formed within English, by derivation; modelled on a German lexical item. Etymons: ganglion n., -oside suffix.

Etymology: < gangli- (in ganglion n.) + -oside suffix, after German Ganglioside (E. Klenk 1942, in Zeitschr. f. physiol. Chem. 273 76).

Biochemistry.

Any of a class of sphingolipids that contain a chain of sugar residues including sialic acid, and which are widely distributed in body tissues, esp. as components of cell membranes, but are found in greatest concentration in the nervous system. Cf. cerebroside n.

ΚΠ

1943 Ann. Rev. Biochem. 12 245 They [sc. cerebrosides of a new class] are found in the gray matter of normal brains and, according to Klenk, are constituents of the nerve cells. The term gangliosides has been applied to them by Klenk.

1955 R. J. Rossiter in K. A. C. Elliott et al. Neurochem. ii. 20 In the brains of patients suffering from Tay-Sach's disease the cerebrosides are largely replaced by gangliosides.

1972 Winnipeg Free Press 22 July 25/6 If it [sc. the enzyme hexosaminidase] is missing, then fatty or lipid material called gangliosides..accumulate in the brain cell.

2006 Science 28 Apr. 541/1 One of these receptors [for botulinum toxin] has been known for many years: it consists of gangliosides, complex glycolipids that are specifically localized on the outer surface of neuronal plasma membranes.

This entry has been updated (OED Third Edition, March 2013; most recently modified version published online March 2022).

单词	ganglioside
释义	gangliosiden. Brit. /ˈɡaŋɡlɪə(ʊ)sʌɪd/, U.S. /ˈɡæŋɡliəˌsaɪd/ Origin: Formed within English, by derivation; modelled on a German lexical item. Etymons: ganglion n., -oside suffix. Etymology: < gangli- (in ganglion n.) + -oside suffix, after German Ganglioside (E. Klenk 1942, in Zeitschr. f. physiol. Chem. 273 76). Biochemistry. Any of a class of sphingolipids that contain a chain of sugar residues including sialic acid, and which are widely distributed in body tissues, esp. as components of cell membranes, but are found in greatest concentration in the nervous system. Cf. cerebroside n. ΚΠ 1943 Ann. Rev. Biochem. 12 245 They [sc. cerebrosides of a new class] are found in the gray matter of normal brains and, according to Klenk, are constituents of the nerve cells. The term gangliosides has been applied to them by Klenk. 1955 R. J. Rossiter in K. A. C. Elliott et al. Neurochem. ii. 20 In the brains of patients suffering from Tay-Sach's disease the cerebrosides are largely replaced by gangliosides. 1972 Winnipeg Free Press 22 July 25/6 If it [sc. the enzyme hexosaminidase] is missing, then fatty or lipid material called gangliosides..accumulate in the brain cell. 2006 Science 28 Apr. 541/1 One of these receptors [for botulinum toxin] has been known for many years: it consists of gangliosides, complex glycolipids that are specifically localized on the outer surface of neuronal plasma membranes. This entry has been updated (OED Third Edition, March 2013; most recently modified version published online March 2022). < n.1943
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