GABAergicadj.

Brit.

/ˌɡabə(r)ˈəːdʒɪk/, U.S.

/ˌɡæbəˈərdʒɪk/

Forms: 1900s– GABAergic, 1900s– gabergic.

Origin: Formed within English, by derivation. Etymons: GABA n. at G n. Initialisms, -ergic suffix.

Etymology: < GABA n. at G n. Initialisms + -ergic suffix.

Physiology.

Designating parts of the nervous system that utilize gamma-aminobutyric acid as a neurotransmitter or neuromodulator; of, relating to, or affecting such structures or such neurotransmission.

ΚΠ

1972 Brain Res. 40 228 Purkinje cells in the vermis send GABA-ergic fibres to the dorsal half of the ipsilateral lateral vestibular nucleus.

1975 Adv. Biochem. Psychopharmacol. 14 56 It should be pointed out that GABA-ergic drugs such as p-chlorphenyl-GABA also reduce arterial blood pressure, cause bradycardia, and slow respiration rate.

1987 Nature 17 Dec. 652/1 The effect of bicuculline treatment suggests that this reduction is due to GABAergic inhibition.

1991 J. R. Cooper et al. Biochem. Basis Neuropharmacol. (ed. 6) vii. 151 (heading) The major exception is the interaction of drugs with GABAergic autoreceptors to modulate both the physiological activity of GABA neurons and the release and synthesis of GABA.

2006 G. Buzsáki Rhythms of Brain vii. 180 These GABAergic nuclei compose a continuous system that cooperatively affects first-order and higher order nuclei of the thalamus.

This entry has been updated (OED Third Edition, June 2018; most recently modified version published online March 2022).

单词	gabaergic
释义	GABAergicadj. Brit. /ˌɡabə(r)ˈəːdʒɪk/, U.S. /ˌɡæbəˈərdʒɪk/ Forms: 1900s– GABAergic, 1900s– gabergic. Origin: Formed within English, by derivation. Etymons: GABA n. at G n. Initialisms, -ergic suffix. Etymology: < GABA n. at G n. Initialisms + -ergic suffix. Physiology. Designating parts of the nervous system that utilize gamma-aminobutyric acid as a neurotransmitter or neuromodulator; of, relating to, or affecting such structures or such neurotransmission. ΚΠ 1972 Brain Res. 40 228 Purkinje cells in the vermis send GABA-ergic fibres to the dorsal half of the ipsilateral lateral vestibular nucleus. 1975 Adv. Biochem. Psychopharmacol. 14 56 It should be pointed out that GABA-ergic drugs such as p-chlorphenyl-GABA also reduce arterial blood pressure, cause bradycardia, and slow respiration rate. 1987 Nature 17 Dec. 652/1 The effect of bicuculline treatment suggests that this reduction is due to GABAergic inhibition. 1991 J. R. Cooper et al. Biochem. Basis Neuropharmacol. (ed. 6) vii. 151 (heading) The major exception is the interaction of drugs with GABAergic autoreceptors to modulate both the physiological activity of GABA neurons and the release and synthesis of GABA. 2006 G. Buzsáki Rhythms of Brain vii. 180 These GABAergic nuclei compose a continuous system that cooperatively affects first-order and higher order nuclei of the thalamus. This entry has been updated (OED Third Edition, June 2018; most recently modified version published online March 2022). < adj.1972
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