angiotensinn.
/ˌan(d)ʒɪə(ʊ)ˈtɛnsɪn/, U.S. /ˌændʒioʊˈtɛnsᵻn/, /ˌændʒiəˈtɛnsᵻn/ Biochemistry and Physiology.
1. An octapeptide (peptide of eight amino acids) that causes blood vessels to constrict and stimulates the production of aldosterone, thus increasing blood pressure. More fully angiotensin II.Earlier names for this peptide were hypertensin and angiotonin.
ΘΚΠ
the world > life > biology > substance > process stimulators or inhibitors > hormone > [noun] > other hormones
thyro-iodine1896
parathormone1925
parathyroid hormone1925
oestrin1926
oestrogen1927
relaxin1930
theelin1930
prolan1931
galactin1932
inhibin1932
prolactin1932
oestriol1933
oestrone1933
oestradiol1934
adrenocorticotrophin1943
pancreozymin1943
ADH1945
adrenocorticotropin1945
cortisone1949
mineralocorticoid1950
electrocortin1953
aldosterone1954
angiotensin1958
melatonin1958
calcitonin1961
zeranol1971
amylin1988
adiponectin1999
adipokine2001
1958 E. Braun-Menendez & I. H. Page in Science 31 Jan. 242/3 The peptide received two trivial names, angiotonin and hypertensin... We propose the simplified name, angiotensin.
1992 Sci. News 1 Feb. 71/1 The fat cells in different parts of the body bind to different amounts of angiotensin II.
2002 P. Thomas What works, what Doesn't x. 137 Liquorice can cause potassium loss, sodium retention and suppression of the renin-angiotensin-aldosteron system (which regulates blood pressure and water balance).
2. angiotensin I n. a peptide of ten amino acids, derived from angiotensinogen, that is the physiologically inactive precursor of angiotensin II.An earlier name for angiotensin I was hypertensin I.
ΚΠ
1959 Sci. Amer. Mar. 56/2 They [sc. Skeggs and Kahn] identified one of these, ‘angiotensin I’, as the direct product of the action of renin on the substrate.
2003 J. Auer in A. Mozayani & L. Raymon Handbk. Drug Interactions vii. 244 The same enzyme that converts angiotensin I to angiotensin II is also responsible for inactivation of the vasodepressor hormone bradykinin.
Compounds
angiotensin converting enzyme n. an enzyme that converts angiotensin I to angiotensin II; abbreviated ACE.An earlier name for this enzyme was hypertensin converting enzyme.
ΘΚΠ
the world > life > biology > biological processes > genetic activity > genetic components > [noun] > nucleic acid > enzymes
galactase1898
cellulase1901
nuclease1902
xanthine oxidase1905
exoenzyme1908
glucosidase1909
galactase1910
nucleosidase1911
nucleotidase1911
adenosine deaminase1913
cellobiase1919
hydratase1922
activase1928
hexokinase1930
histaminase1930
kallikrein1930
Michaelis constant1930
cholinesterase1932
phosphodiesterase1932
chymotrypsin1933
glycosidase1933
rhodanese1933
acetylcholinesterase1937
prolidase1937
diaphorase1938
aconitase1939
hyaluronidase1940
transaminase1940
hydrase1943
isomerase1943
lactoperoxidase1943
streptokinase1944
pectinesterase1945
pectinmethylesterase1945
phosphokinase1946
alliinase1947
CoA1947
phosphotransferase1948
polymerase1948
transferase1948
elastase1949
amyloglucosidase1950
transacetylase1950
transhydrogenase1952
hydroxylase1953
kinase1953
transketolase1953
synthase1954
hexosaminidase1955
translocase1957
angiotensinase1958
angiotensin converting enzyme1960
photoenzyme1960
acetyltransferase1961
adenyl cyclase1961
adenylate cyclase1962
replicase1962
ADA1963
transcriptase1963
adenylyl cyclase1964
recombinase1964
laminarinase1966
nickase1967
acrosin1970
reverse transcriptase1970
cellobiohydrolase1972
cyclooxygenase1974
laminaranase1974
primase1977
helicase1978
monodeiodinase1978
transposase1979
maturase1980
1960 L. T. Skeggs in M. Schachter Polypeptides 111 Helmer..had found a factor in plasma which enhanced the activity of angiotensin, and suggested to us that this factor might be angiotensin converting enzyme.
2018 express.co.uk (Nexis) 1 May Some probiotic bacteria that ferment milk to create yogurt produce substances that inhibit angiotensin converting enzyme.
angiotensin converting enzyme inhibitor n. any compound that inhibits the conversion of angiotensin I to angiotensin II; spec. any of a class of drugs with this property, used in the treatment of hypertension and heart disease (= ACE inhibitor n. at ACE n.2 Compounds).
ΚΠ
1971 Biochemistry 10 4033 (title) Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca.
2004 Globe & Mail (Toronto) 10 Nov. a21/3 Virtually all diabetics who have one of these three forms of cardiovascular disease should be prescribed three types of heart drugs: angiotensin converting enzyme inhibitors (to lower blood pressure), statins (to control cholesterol), and antiplatelet agents like Aspirin.
Derivatives
ˌangioˈtensinase n. (a) an enzyme that converts angiotensin I to angiotensin II (= angiotensin converting enzyme n. at Compounds) (now historical and rare); (b) any enzyme that breaks down or inactivates angiotensin II.
ΘΚΠ
the world > life > biology > biological processes > genetic activity > genetic components > [noun] > nucleic acid > enzymes
galactase1898
cellulase1901
nuclease1902
xanthine oxidase1905
exoenzyme1908
glucosidase1909
galactase1910
nucleosidase1911
nucleotidase1911
adenosine deaminase1913
cellobiase1919
hydratase1922
activase1928
hexokinase1930
histaminase1930
kallikrein1930
Michaelis constant1930
cholinesterase1932
phosphodiesterase1932
chymotrypsin1933
glycosidase1933
rhodanese1933
acetylcholinesterase1937
prolidase1937
diaphorase1938
aconitase1939
hyaluronidase1940
transaminase1940
hydrase1943
isomerase1943
lactoperoxidase1943
streptokinase1944
pectinesterase1945
pectinmethylesterase1945
phosphokinase1946
alliinase1947
CoA1947
phosphotransferase1948
polymerase1948
transferase1948
elastase1949
amyloglucosidase1950
transacetylase1950
transhydrogenase1952
hydroxylase1953
kinase1953
transketolase1953
synthase1954
hexosaminidase1955
translocase1957
angiotensinase1958
angiotensin converting enzyme1960
photoenzyme1960
acetyltransferase1961
adenyl cyclase1961
adenylate cyclase1962
replicase1962
ADA1963
transcriptase1963
adenylyl cyclase1964
recombinase1964
laminarinase1966
nickase1967
acrosin1970
reverse transcriptase1970
cellobiohydrolase1972
cyclooxygenase1974
laminaranase1974
primase1977
helicase1978
monodeiodinase1978
transposase1979
maturase1980
the world > life > biology > biological processes > genetic activity > genetic components > [adjective] > of nucleic acid > of enzymes
constitutive1932
Michaelis–Menten1934
inducible1953
angiotensinase1958
1958 E. Braun-Menendez & I. H. Page in Science 31 Jan. 242/3 We propose the simplified name, angiotensin, and its derivatives angiotensinase and angiotensinogen.
1961 Biochem. Pharmacol. 8 112/1 The enzymes which metabolize these substrates are often named after one substrate, for example: angiotensinase, kininase, [etc.]
2013 D. French & A. Wu in D. Wild Immunoassay Handbk. (ed. 4) ix. 829/1 Angiotensin II is an extremely potent vasoconstrictor but has a very short half-life, being degraded by angiotensinases to inactive fragments.
ˌangiotenˈsinogen n. [compare earlier hypertensinogen n. at hypertensin n. Derivatives] a plasma protein synthesized by the liver, from which angiotensin I is produced by the action of the enzyme renin.An earlier name for angiotensinogen was hypertensinogen.
ΘΚΠ
the world > life > the body > vascular system > blood > components of blood > blood corpuscle or plate > [noun] > red cells or corpuscles > haemoglobin > forms or parts of
globulin1831
haematosin1834
haemato-crystallin1865
oxyhaemoglobin1869
methaemoglobin1870
globin1872
haematogen1890
methaemoglobulin1890
haemagglutinin1904
haem1925
hypertensinogen1941
angiotensinogen1958
1958 E. Braun-Menendez & I. H. Page in Science 31 Jan. 242/3 We propose the simplified name, angiotensin, and its derivatives angiotensinase and angiotensinogen.
2010 Guardian (Nexis) 7 Oct. (Home section) 12 Angiotensinogen changes shape when it is oxidised by reactive molecules in the blood.
This entry has been updated (OED Third Edition, September 2019; most recently modified version published online December 2021).
<
n.1958