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单词 frameshift mutation
释义

> as lemmas

frameshift mutation
frameshift n. Molecular Biology displacement of the reading frame in a nucleic acid sequence; spec. (more fully frameshift mutation) any mutation which results in this by insertion or deletion of nucleotides in numbers other than multiples of three.
ΚΠ
1961 F. H. C. Crick et al. in Nature 30 Dec. 1229/2 The simplest postulate to make is that the shift of the reading frame produces some triplets the reading of which is ‘unacceptable’.]
1965 Q. Rev. Biol. 40 264/2 Their complements, with reversed polarity, and no frame shift, are: Up Up A and Cp Up A.
1988 L. Stryer Biochem. (ed. 3) vii. 171 The deletion or addition of a nucleotide, a frameshift mutation, leads to an entirely different amino acid sequence on the distal side of the mutation.
2002 Proc. National Acad. Sci. U.S.A. 99 16616/1 This deletion causes a frameshift and the introduction of a stop codon.
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