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单词 2′,3′-dideoxyinosine
释义

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2′,3′-dideoxyinosine
Any of several isomeric purine nucleoside analogues which inhibit the replication of certain viruses; spec. (in full 2′,3′-dideoxyinosine), one which has been used in the treatment of HIV infection.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for HIV infection
dideoxycytidine1965
azidothymidine1974
dideoxyinosine1975
AZT1985
ddC1987
Retrovir1987
zidovudine1987
ddI1989
didanosine1990
nevirapine1991
zalcitabine1991
non-nucleoside1993
1975 Cancer Res. 35 1548/1 2′,3′-Dideoxyinosine had absorbance maxima at 248nm (pH 2) and 254nm (pH 12).
1980 Biochemistry 19 105/1 Similar substrate activation occurred at high concentrations of the sugar-modified analogues 5′-deoxy- and 2′,5′-dideoxyinosine.
1989 New Eng. Jrnl. Med. 23 Nov. 1478/1 Dideoxyinosine should be considered for development as an alternative to AZT in patients with impaired hematopoiesis.
1990 New Scientist 26 May 32 The start of Britain's trials of the AIDS drug dideoxyinosine (DDI) this week comes shortly after the publication..of initial studies on the drug's safety.
1992 Boston Globe 26 July 6/3 Some newly approved drugs like dideoxyinosine, or DDI, work better in combination with the original standby, zidovudine, or AZT.
extracted from dideoxyinosinen.
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