| 单词 | 2′,3′-dideoxycytidine |
| 释义 | > as lemmas2′,3′-dideoxycytidine Either of two isomeric pyrimidine nucleoside analogues having the formula C9H13N3O3; spec. (in full 2′,3′-dideoxycytidine) a compound which inhibits the replication of certain viruses (including HIV) and has been used experimentally in the treatment of HIV infection. Abbreviated ddc. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for HIV infection dideoxycytidine1965 azidothymidine1974 dideoxyinosine1975 AZT1985 ddC1987 Retrovir1987 zidovudine1987 ddI1989 didanosine1990 nevirapine1991 zalcitabine1991 non-nucleoside1993 1965 Jrnl. Org. Chem. 30 3068/1 Hydrogenation..gave the desired 2′,5′-dideoxycytidine as the hydriodide salt. 1965 Jrnl. Org. Chem. 30 3069/1 A desirable derivative of 2′-deoxycytidine of potential biological significance is 2′,3′-dideoxycytidine. 1980 Jrnl. Biol. Chem. 255 11850/2 Dideoxycytidine triphosphate..is a potent inhibitor of DNA polymerases β and γ. 1988 New Scientist 21 Jan. 28/1 A preliminary trial of dideoxycytidine (ddC) in 20 patients with AIDS or severe disease caused by HIV infection. 1992 Independent 1 Feb. 6/4 There is a third anti-retroviral, DDC (dideoxycytidine), and now large-scale trials into combination therapy..are under way. < as lemmas |
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