ethacrynicadj.

Brit.

/ɛθəˈkrʌɪnɪk/, U.S.

/ˌɛθəˈkraɪnɪk/

Forms: 1900s– etacrynic, 1900s– ethacrynic.

Origin: Formed within English, by derivation. Etymons: eth- comb. form, acryl n., phenoxy- comb. form, -ic suffix.

Etymology: < eth- comb. form + acry- (in acryl n.) + -n- (in phenoxy- comb. form) + -ic suffix, elements of the chemical name.

Pharmacology.

ethacrynic acid n. a diuretic that acts on the ascending portion of the loop of Henle (see Henle n. 2) and is used (now rarely) esp. in the treatment of oedema resulting from heart failure.Chemical name: (2,3-dichloro-4-(2-ethylacryloyl)phenoxy)acetic acid; C₁₃H₁₂Cl₂O₄.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > cleansing or expelling medicines > [noun] > diuretic > specific

Haarlem oil1885

Salyrgan1924

mersalyl1936

acetazolamide1954

chlorothiazide1957

thiazide1959

triamterene1962

ethacrynic acid1963

frusemide1963

1963 Brit. Med. Jrnl. 8 June 1521/1 There are occasional patients who do not respond adequately to these diuretics, and it was with these ‘resistant’ patients in mind that we investigated the diuretic properties of a new drug, ethacrynic acid (MK-595).

1987 M. J. Neal Med. Pharmacol. at Glance xiii. 33/2 Over-enthusiastic use of loop diuretics, especially ethacrynic acid..can cause deafness.

2003 D. Cairns Essent. Pharmaceut. Chem. (ed. 2) iii. 59 For aspirin and etacrynic acid..99.99% of a given dose of drug will be ionised at the pH of blood.

2012 Gympie (Queensland) Times 3 Feb. 23 During an inspection of the..stables last October, stewards took possession of an unlabelled substance. Subsequent analysis showed that it contained ethacrynic acid, a prescription-only substance.

This entry has been updated (OED Third Edition, March 2014; most recently modified version published online March 2022).

单词	ethacrynic
释义	ethacrynicadj. Brit. /ɛθəˈkrʌɪnɪk/, U.S. /ˌɛθəˈkraɪnɪk/ Forms: 1900s– etacrynic, 1900s– ethacrynic. Origin: Formed within English, by derivation. Etymons: eth- comb. form, acryl n., phenoxy- comb. form, -ic suffix. Etymology: < eth- comb. form + acry- (in acryl n.) + -n- (in phenoxy- comb. form) + -ic suffix, elements of the chemical name. Pharmacology. ethacrynic acid n. a diuretic that acts on the ascending portion of the loop of Henle (see Henle n. 2) and is used (now rarely) esp. in the treatment of oedema resulting from heart failure.Chemical name: (2,3-dichloro-4-(2-ethylacryloyl)phenoxy)acetic acid; C₁₃H₁₂Cl₂O₄. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > cleansing or expelling medicines > [noun] > diuretic > specific Haarlem oil1885 Salyrgan1924 mersalyl1936 acetazolamide1954 chlorothiazide1957 thiazide1959 triamterene1962 ethacrynic acid1963 frusemide1963 1963 Brit. Med. Jrnl. 8 June 1521/1 There are occasional patients who do not respond adequately to these diuretics, and it was with these ‘resistant’ patients in mind that we investigated the diuretic properties of a new drug, ethacrynic acid (MK-595). 1987 M. J. Neal Med. Pharmacol. at Glance xiii. 33/2 Over-enthusiastic use of loop diuretics, especially ethacrynic acid..can cause deafness. 2003 D. Cairns Essent. Pharmaceut. Chem. (ed. 2) iii. 59 For aspirin and etacrynic acid..99.99% of a given dose of drug will be ionised at the pH of blood. 2012 Gympie (Queensland) Times 3 Feb. 23 During an inspection of the..stables last October, stewards took possession of an unlabelled substance. Subsequent analysis showed that it contained ethacrynic acid, a prescription-only substance. This entry has been updated (OED Third Edition, March 2014; most recently modified version published online March 2022). < adj.1963
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