amantadinen.
Pharmacol.
A derivative, C10H17N.HCl, of adamantane which inhibits the action of some viruses, and is used prophylactically against influenza type A2 and also in the treatment of Parkinsonism. Also amantadine hydrochloride.
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amantadine1964
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amantadine1964
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1964 Science 15 May 862/1, 1-Adamantanamine (amantadine), a stable, colorless, crystalline amine with an unusual symmetrical structure, reproducibly and selectively inhibits influenza viruses in tissue culture, chick embryos, and mice.
1977 Lancet 23 Apr. 904/1 It is difficult to know whether to prescribe levodopa, bromocriptine, or amantadine for patients with Parkinson's disease who also have heart-disease, because all these drugs may be cardiotoxic.
1977 Martindale's Extra Pharmacopoeia (ed. 27) 855/2 Amantadine hydrochloride is an antiviral agent which probably inhibits penetration of the virus into the host cell. It has no virucidal actions.
1983 New Scientist 10 Mar. 644/1 The third anti-viral drug available now is a cage-like hydrocarbon amine molecule called amantadine.
This entry has not yet been fully updated (first published 1989; most recently modified version published online November 2010).
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n.1964