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单词 allostery
释义

allosteryn.

Brit. /ˈaləstɛri/, /ˈaləstɪəri/, U.S. /ˈæləˌstɪri/
Origin: Formed within English, by derivation; probably modelled on a French lexical item. Etymons: allosteric adj., -y suffix3.
Etymology: < alloster- (in allosteric adj.) + -y suffix3, probably after French allostérie (1964 or earlier). Compare slightly earlier allosterism n.
Biochemistry.
(The theory of) allosteric regulation of protein activity.
ΚΠ
1965 Jrnl. Molecular Biol. 12 326 The evidence even seems to indicate that repressor is a polymeric protein, as proposed in the allostery model, although there is no evidence in the present studies that the state of polymerization is affected by inducer.
1975 Nature 4 Sept. 76/2 He..provided evidence for a low molecular weight compound such as a steroid hormone, specifically changing the conformation of a protein molecule. This concept, subsequently termed allostery by others, is an important one not only in endocrinology but for most of molecular biology and biochemistry.
1982 J. L. York in T. M. Devlin Textbk. Biochem. iv. 171 (heading) Allostery and cooperativity.
2001 M. Hoagland et al. Exploring Way Life Works vi. 219 Allostery has enabled life to master the art not only of molecular control, but also of molecular communication.
This entry has been updated (OED Third Edition, September 2012; most recently modified version published online December 2021).
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n.1965
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