单词 | dideoxyinosine |
释义 | dideoxyinosinen. Pharmacology. Any of several isomeric purine nucleoside analogues which inhibit the replication of certain viruses; spec. (in full 2′,3′-dideoxyinosine), one which has been used in the treatment of HIV infection. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for HIV infection dideoxycytidine1965 azidothymidine1974 dideoxyinosine1975 AZT1985 ddC1987 Retrovir1987 zidovudine1987 ddI1989 didanosine1990 nevirapine1991 zalcitabine1991 non-nucleoside1993 1975 Cancer Res. 35 1548/1 2′,3′-Dideoxyinosine had absorbance maxima at 248nm (pH 2) and 254nm (pH 12). 1980 Biochemistry 19 105/1 Similar substrate activation occurred at high concentrations of the sugar-modified analogues 5′-deoxy- and 2′,5′-dideoxyinosine. 1989 New Eng. Jrnl. Med. 23 Nov. 1478/1 Dideoxyinosine should be considered for development as an alternative to AZT in patients with impaired hematopoiesis. 1990 New Scientist 26 May 32 The start of Britain's trials of the AIDS drug dideoxyinosine (DDI) this week comes shortly after the publication..of initial studies on the drug's safety. 1992 Boston Globe 26 July 6/3 Some newly approved drugs like dideoxyinosine, or DDI, work better in combination with the original standby, zidovudine, or AZT. This entry has not yet been fully updated (first published 1997; most recently modified version published online June 2018). < n.1975 |
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