amitriptylinen.

/æmɪˈtrɪptɪliːn/

Etymology: < ami- (in amino- comb. form) + tri- comb. form + -ptyl (in heptyl n. at heptane n. Derivatives) + -ine suffix⁵: compare protriptyline n.

Pharmacol.

A tricyclic antidepressant drug with sedative properties, C₂₀H₂₃N, given as the hydrochloride.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs

Marsilid1952

iproniazid1953

levallorphan1953

imipramine1958

Tofranil1958

isocarboxazid1959

Marplan1959

Nardil1959

nialamide1959

Niamid1959

phenelzine1959

tranylcypromine1959

Parnate1960

amitriptyline1961

monoamine oxidase inhibitor1962

nortriptyline1962

protriptyline1963

MAOI1965

maprotiline1970

mianserin1970

amoxapine1971

fluoxetine1975

paroxetine1977

Prozac1985

Seroxat1985

1961 Lancet 10 June 1287/2 Amitriptyline hydrochloride (‘Tryptizol’), a new antidepressant drug recently released to hospitals.

1963 Amer. Jrnl. Psychiatry 120 594/1 In an attempt to evaluate a derivative of amitriptyline, MK-240 (protryptyline), where the ‘sleepiness’ was removed by a change in the chemical formula, the drug was studied in 61 patients with various types of depression.

1965 Psychosomatics VI. 346/1 Protriptyline is at least five times as active as amitriptyline against depressive reactions.

1979 Daily Tel. 27 Nov. 12/7 A third of the prescriptions were for imipramine and amitriptyline, and two-thirds of these were for branded products.

1981 Approved Names (Brit. Pharmacopœia Comm.) 4 Amitriptyline, 3-(10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5-ylidene)propyldimethylamine.

1982 Sci. Amer. Mar. 112/3 Many of the antidepressant drugs employed in psychiatry, such as amitriptyline (Elavil), block the reuptake of neurotransmitters, but they are not stimulants and they do not induce euphoria.

This entry has not yet been fully updated (first published 1989; most recently modified version published online November 2010).

单词	amitriptyline
释义	amitriptylinen. /æmɪˈtrɪptɪliːn/ Etymology: < ami- (in amino- comb. form) + tri- comb. form + -ptyl (in heptyl n. at heptane n. Derivatives) + -ine suffix⁵: compare protriptyline n. Pharmacol. A tricyclic antidepressant drug with sedative properties, C₂₀H₂₃N, given as the hydrochloride. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs Marsilid1952 iproniazid1953 levallorphan1953 imipramine1958 Tofranil1958 isocarboxazid1959 Marplan1959 Nardil1959 nialamide1959 Niamid1959 phenelzine1959 tranylcypromine1959 Parnate1960 amitriptyline1961 monoamine oxidase inhibitor1962 nortriptyline1962 protriptyline1963 MAOI1965 maprotiline1970 mianserin1970 amoxapine1971 fluoxetine1975 paroxetine1977 Prozac1985 Seroxat1985 1961 Lancet 10 June 1287/2 Amitriptyline hydrochloride (‘Tryptizol’), a new antidepressant drug recently released to hospitals. 1963 Amer. Jrnl. Psychiatry 120 594/1 In an attempt to evaluate a derivative of amitriptyline, MK-240 (protryptyline), where the ‘sleepiness’ was removed by a change in the chemical formula, the drug was studied in 61 patients with various types of depression. 1965 Psychosomatics VI. 346/1 Protriptyline is at least five times as active as amitriptyline against depressive reactions. 1979 Daily Tel. 27 Nov. 12/7 A third of the prescriptions were for imipramine and amitriptyline, and two-thirds of these were for branded products. 1981 Approved Names (Brit. Pharmacopœia Comm.) 4 Amitriptyline, 3-(10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5-ylidene)propyldimethylamine. 1982 Sci. Amer. Mar. 112/3 Many of the antidepressant drugs employed in psychiatry, such as amitriptyline (Elavil), block the reuptake of neurotransmitters, but they are not stimulants and they do not induce euphoria. This entry has not yet been fully updated (first published 1989; most recently modified version published online November 2010). < n.1961
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