degranulatev.

/diːˈɡranjʊleɪt/

Etymology: < de- prefix 2a + granulate v.

Medicine.

a. transitive. To cause the degranulation of; to remove granules or granularity from.

ΘΚΠ

the world > life > biology > substance > cell > cell substance > [verb (transitive)] > degranulate

degranulate1952

1952 [see degranulated adj. at Derivatives].

1971 Nature 9 July 104/2 Carbon tetrachloride degranulates rough membranes only after activation by the hydroxylase system.

1977 Lancet 20 Aug. 389/1 Plasma or serum from this patient degranulated eosinophils from normal individuals, perhaps indicating an autoimmune mechanism.

b. intransitive. To undergo degranulation; to lose granules or granularity.

ΘΚΠ

the world > life > biology > substance > cell > cell substance > [verb (intransitive)] > degranulate

degranulate1963

1963 [see degranulating n. and adj. at Derivatives].

1978 Nature 22 June 619/1 In the presence of reaginic antibody and antigen, mast cells degranulate, releasing vasoactive substances which cause increased mucosal permeability.

1982 Sci. Amer. Aug. 85/1 The mast cell degranulates: the granules move to the surface of the cell and release their contents into the surrounding tissue.

1988 Nature 22 Sept. 292/1 The issue of whether basophils degranulate at infinite concentrations of IgE in a cyclic manner..is of great scientific and clinical interest.

Derivatives

deˈgranulated adj.

ΘΚΠ

the world > life > biology > substance > cell > cell substance > [adjective] > undergoing or having undergone degranulation

degranulated1952

degranulating1963

1952 Proc. Soc. Exper. Biol. & Med. 80 678/1 In human patients the mast cells of dermal connective tissue decreased in number and became degranulated.

1975 Nature 9 Oct. 511/1 Electron microscopic observations of haemostatic plugs in rabbits and dogs have shown that the platelets are mostly degranulated.

deˈgranulating n. and adj.

ΘΚΠ

the world > life > biology > substance > cell > cell substance > [adjective] > undergoing or having undergone degranulation

degranulated1952

degranulating1963

1963 Jrnl. Amer. Med. Assoc. 20 Apr. 174/1 Rabbits in good health are regularly satisfactory, but occasionally degranulating cells will be seen in the control.

1989 New Scientist 15 July 49/1 The drug sodium cromoglycate is known to prevent mast cells from releasing their mediators (degranulating).

This entry has not yet been fully updated (first published 1993; most recently modified version published online September 2018).

单词	degranulate
释义	degranulatev. /diːˈɡranjʊleɪt/ Etymology: < de- prefix 2a + granulate v. Medicine. a. transitive. To cause the degranulation of; to remove granules or granularity from. ΘΚΠ the world > life > biology > substance > cell > cell substance > [verb (transitive)] > degranulate degranulate1952 1952 [see degranulated adj. at Derivatives]. 1971 Nature 9 July 104/2 Carbon tetrachloride degranulates rough membranes only after activation by the hydroxylase system. 1977 Lancet 20 Aug. 389/1 Plasma or serum from this patient degranulated eosinophils from normal individuals, perhaps indicating an autoimmune mechanism. b. intransitive. To undergo degranulation; to lose granules or granularity. ΘΚΠ the world > life > biology > substance > cell > cell substance > [verb (intransitive)] > degranulate degranulate1963 1963 [see degranulating n. and adj. at Derivatives]. 1978 Nature 22 June 619/1 In the presence of reaginic antibody and antigen, mast cells degranulate, releasing vasoactive substances which cause increased mucosal permeability. 1982 Sci. Amer. Aug. 85/1 The mast cell degranulates: the granules move to the surface of the cell and release their contents into the surrounding tissue. 1988 Nature 22 Sept. 292/1 The issue of whether basophils degranulate at infinite concentrations of IgE in a cyclic manner..is of great scientific and clinical interest. Derivatives deˈgranulated adj. ΘΚΠ the world > life > biology > substance > cell > cell substance > [adjective] > undergoing or having undergone degranulation degranulated1952 degranulating1963 1952 Proc. Soc. Exper. Biol. & Med. 80 678/1 In human patients the mast cells of dermal connective tissue decreased in number and became degranulated. 1975 Nature 9 Oct. 511/1 Electron microscopic observations of haemostatic plugs in rabbits and dogs have shown that the platelets are mostly degranulated. deˈgranulating n. and adj. ΘΚΠ the world > life > biology > substance > cell > cell substance > [adjective] > undergoing or having undergone degranulation degranulated1952 degranulating1963 1963 Jrnl. Amer. Med. Assoc. 20 Apr. 174/1 Rabbits in good health are regularly satisfactory, but occasionally degranulating cells will be seen in the control. 1989 New Scientist 15 July 49/1 The drug sodium cromoglycate is known to prevent mast cells from releasing their mediators (degranulating). This entry has not yet been fully updated (first published 1993; most recently modified version published online September 2018). < v.1952
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