cytotoxicadj.

Brit.

/ˌsʌɪtə(ʊ)ˈtɒksɪk/, U.S.

/ˌsaɪdəˈtɑksɪk/

Origin: Formed within English, by compounding; originally modelled on a French lexical item. Etymons: cyto- comb. form, toxic adj.

Etymology: < cyto- comb. form + toxic adj., originally after French cytotoxique (E. Metchnikoff 1900, in Ann. de l'Inst. Pasteur 14 374). Compare slightly earlier cytotoxin n.

1. Causing death or injury to cells.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > toxin > [adjective]

cytotoxic1902

1902 Lancet 11 Oct. 980/1 This is true especially in the case of cytotoxic sera.

1943 Brit. Med. Jrnl. 14 Aug. 203/1 The favourable effect of antireticular cytotoxic serum on the course of infectious diseases of the nervous system.

1961 New Scientist 19 Oct. 186/1 The so-called cytotoxic drugs used in the treatment of cancer.

1985 W. Frain-Bell Cutaneous Photobiol. i. 1 At the time when the earth was cooling, the cytotoxic u.v. C waveband was prevented from reaching the earth, thus allowing living cells to survive.

2007 R. W. Ruddon Cancer Biol. (ed. 4) ix. 489/2 Damage to cells' genomic apparatus comes from both external and intrinsic sources. The former includes exposure to irradiation, cytotoxic chemicals, sunlight,..etc.

2. Immunology. Designating a class of T lymphocytes that can kill target cells bearing viral, tumour, or other foreign antigens; of or relating to such cells.

ΚΠ

1971 K. T. Brunner & J. C. Cerottini in B. Amos Progress in Immunol. 385 (title) Cytotoxic lymphocytes as effector cells of cell-mediated immunity.

1986 N.Y. Times 25 Sept. a20/3 Chimpanzees were also tested with the remodeled vaccinia virus and..the animals produced both the helper T cells that aid in antibody production and cytotoxic T cells that can actually kill infected cells.

1993 Cell 73 225/1 Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established.

2003 Dominion Post (Wellington, N.Z.) (Nexis) 17 Jan. 5 The vaccine would be used to stimulate increased production of cytotoxic T lymphocytes.

This entry has been updated (OED Third Edition, November 2010; most recently modified version published online March 2022).

单词	cytotoxic
释义	cytotoxicadj. Brit. /ˌsʌɪtə(ʊ)ˈtɒksɪk/, U.S. /ˌsaɪdəˈtɑksɪk/ Origin: Formed within English, by compounding; originally modelled on a French lexical item. Etymons: cyto- comb. form, toxic adj. Etymology: < cyto- comb. form + toxic adj., originally after French cytotoxique (E. Metchnikoff 1900, in Ann. de l'Inst. Pasteur 14 374). Compare slightly earlier cytotoxin n. 1. Causing death or injury to cells. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > toxin > [adjective] cytotoxic1902 1902 Lancet 11 Oct. 980/1 This is true especially in the case of cytotoxic sera. 1943 Brit. Med. Jrnl. 14 Aug. 203/1 The favourable effect of antireticular cytotoxic serum on the course of infectious diseases of the nervous system. 1961 New Scientist 19 Oct. 186/1 The so-called cytotoxic drugs used in the treatment of cancer. 1985 W. Frain-Bell Cutaneous Photobiol. i. 1 At the time when the earth was cooling, the cytotoxic u.v. C waveband was prevented from reaching the earth, thus allowing living cells to survive. 2007 R. W. Ruddon Cancer Biol. (ed. 4) ix. 489/2 Damage to cells' genomic apparatus comes from both external and intrinsic sources. The former includes exposure to irradiation, cytotoxic chemicals, sunlight,..etc. 2. Immunology. Designating a class of T lymphocytes that can kill target cells bearing viral, tumour, or other foreign antigens; of or relating to such cells. ΚΠ 1971 K. T. Brunner & J. C. Cerottini in B. Amos Progress in Immunol. 385 (title) Cytotoxic lymphocytes as effector cells of cell-mediated immunity. 1986 N.Y. Times 25 Sept. a20/3 Chimpanzees were also tested with the remodeled vaccinia virus and..the animals produced both the helper T cells that aid in antibody production and cytotoxic T cells that can actually kill infected cells. 1993 Cell 73 225/1 Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. 2003 Dominion Post (Wellington, N.Z.) (Nexis) 17 Jan. 5 The vaccine would be used to stimulate increased production of cytotoxic T lymphocytes. This entry has been updated (OED Third Edition, November 2010; most recently modified version published online March 2022). < adj.1902
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