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单词 concanavalin
释义

concanavalinn.

/kɒnkəˈnavəlɪn/
Etymology: < con- prefix + canavalin (see quot. 1917), < modern Latin Canavalia , generic name of the jack bean ( < a language of the Malabar coast + -ia suffix1): see -in suffix1.
Biochemistry.
Either of two globulins (concanavalin A, B) originally isolated from the jack bean; spec. concanavalin A, a powerful agglutinin of blood.
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the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > types of
Russell body1892
precipitin1900
nephrotoxin1902
hepatotoxin1903
opsonin1903
autoantibody1905
concanavalin1917
isoantibody1919
reagin1925
immune globulin1934
macroglobulin1952
immunoglobulin1953
properdin1954
LATS1961
alloantibody1964
xenoantibody1974
monoclonal1980
abzyme1986
1917 Jones & Johns in Jrnl. Biol. Chem. XXVIII. 68 Fractional precipitation of the globulin obtained from the jack bean..enabled us to isolate two globulins... The globulin obtained in the greatest amount..we have named canavalin. Associated with canavalin was..a second globulin which was less soluble and had a much higher sulfur content. To this globulin we have given the name concanavalin.
1919 J. B. Sumner in Jrnl. Biol. Chem. 37 137 The minute amount of material which crystallizes as needles is slowly soluble in 10 per cent salt solution... The author has named this globulin concanavalin B. The third globulin, crystallizing in bisphenoid form, and present in moderate amount, appears to be insoluble in any but concentrated salt solutions... The author proposes to name this globulin concanavalin A.
1935 Jrnl. Immunol. 29 134 We made solutions of canavalin, concanavalin A, concanavalin B, jack bean proteose, and an amorphous..jack bean protein and found that although some agglutinin was present in all of these solutions the activity was slight in relation to the amount of protein in solution.
1936 Jrnl. Bacteriol. 32 229 Concanavalin A readily agglutinates erythrocytes from pH 5·2 to pH 7·5.
1974 N. Sharon in J. B. Pridham Plant Carbohydrate Biochem. xvi. 237 Immobilized concanavalin A has been used for the isolation of immunoglobulins and of glycoprotein enzymes.
1983 D. J. Weatherall et al. Oxf. Textbk. Med. I. iv. 29/2 The plant lectins concanavalin A and phytohaemagglutinin (PHA) are..activators of T cells which induce markedly polyclonal blast transformation with DNA synthesis, and this effect is used as a broad in vitro test of T cell function.
This entry has not yet been fully updated (first published 1989; most recently modified version published online March 2021).
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n.1917
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