alamethicinn.

Brit.

/ˌaləˈmɛθᵻsɪn/, U.S.

/ˌæləˈmɛθəs(ə)n/

Origin: Formed within English, by compounding. Etymons: alanine n., methyl n., rifampicin n.

Etymology: < ala- (in alanine n.) + meth- (in methyl n.) + -icin (in, e.g., rifampicin n. and other antibiotic names; compare -mycin suffix).

Biochemistry.

A cyclic polypeptide, originally obtained from the fungus Trichoderma viride, which is an ionophore for cations and has antibiotic activity; any of a group of compounds structurally related to this.

ΚΠ

1967 Trademark Bull. (Pharmaceutical Manufacturers Assoc.) 17 May 1 Proposed United States Adopted Names (USAN)..‘alamethicin’: antibiotic.

1968 Nature 24 Feb. 713/1 The electrokinetic and chemical data suggest that six or more alamethicin molecules form either carriers or tubular channels through which ions flow across the membrane.

1996 D. J. Aidley & P. R. Stanford Ion Channels iv. 118 A number of natural and synthetic analogues of alamethicin occur, many of them useful as antibiotics.

2009 N. Sewald & H. D. Jakubke Peptides (ed. 2) 149 The alamethicins are rich..in the strongly helicogenic, non-coded α-aminoisobutyric acid.

This entry has been updated (OED Third Edition, September 2012; most recently modified version published online December 2021).

单词	alamethicin
释义	alamethicinn. Brit. /ˌaləˈmɛθᵻsɪn/, U.S. /ˌæləˈmɛθəs(ə)n/ Origin: Formed within English, by compounding. Etymons: alanine n., methyl n., rifampicin n. Etymology: < ala- (in alanine n.) + meth- (in methyl n.) + -icin (in, e.g., rifampicin n. and other antibiotic names; compare -mycin suffix). Biochemistry. A cyclic polypeptide, originally obtained from the fungus Trichoderma viride, which is an ionophore for cations and has antibiotic activity; any of a group of compounds structurally related to this. ΚΠ 1967 Trademark Bull. (Pharmaceutical Manufacturers Assoc.) 17 May 1 Proposed United States Adopted Names (USAN)..‘alamethicin’: antibiotic. 1968 Nature 24 Feb. 713/1 The electrokinetic and chemical data suggest that six or more alamethicin molecules form either carriers or tubular channels through which ions flow across the membrane. 1996 D. J. Aidley & P. R. Stanford Ion Channels iv. 118 A number of natural and synthetic analogues of alamethicin occur, many of them useful as antibiotics. 2009 N. Sewald & H. D. Jakubke Peptides (ed. 2) 149 The alamethicins are rich..in the strongly helicogenic, non-coded α-aminoisobutyric acid. This entry has been updated (OED Third Edition, September 2012; most recently modified version published online December 2021). < n.1967
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