clastogenn.
/ˈklastədʒɛn/ Genetics.
An agent that causes breaks in chromosomes.
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clastogen1970
1970 M. W. Shaw in Ann. Rev. Med. 21 409 A term was needed for the cumbersome phrase ‘chromosome-breaking agent’... The word ‘chromosomoclastogen’ is suggested... In this article the more euphonious form ‘clastogen’ will be used.
1970 M. W. Shaw in Ann. Rev. Med. 21 409 Certain genes, viruses, and protozoa are examples of biological clastogens.
1975 Poultry Sci. 54 310 Failure to detect chromosomal aberrations in either group indicated that Aroclor 1242..is not an effective clastogen.
1988 Human Genetics 80 135 Spontaneous and clastogen-induced damage was analyzed in cultures of peripheral blood lymphocytes.
Derivatives
clastoˈgenic adj. causing breaks in chromosomes.
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the world > life > biology > biological processes > genetic activity > genetic components > [adjective] > chromosome > causing breaks in
clastogenic1970
1970 M. W. Shaw in Ann. Rev. Med. 21 410 Some chemicals which are clastogenic may also be mutagenic.
1990 Mutagenesis 5 588/1 α-Ni3S2..presented a significant clastogenic activity which could be made evident in vitro by cytogenetic analysis of cultured human lymphocytes.
clastogeˈnicity n.
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the world > life > biology > biological processes > genetic activity > genetic components > [noun] > chromosome > ability to cause breaks in
clastogenicity1970
1970 M. W. Shaw in Ann. Rev. Med. 21 411 Among the DNA inhibitors, azascrine, mitomycin C, phleomycin, and streptonigrin have been tested for clastogenicity.
1977 Mutation Res. 47 183 Most of the in vitro studies performed on the clastogenicity of LSD indicate either suppression of mitosis or enhanced chromosome damage.
This entry has not yet been fully updated (first published 1997; most recently modified version published online December 2018).
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n.1970