citrovorumn.

Brit.

/sɪtrəˈvɔːrəm/, U.S.

/ˌsɪtrəˈvɔrəm/

Origin: A borrowing from Latin. Etymon: Latin citrovorum.

Etymology: < scientific Latin citrovorum, former specific epithet (1939 or earlier, in Leuconostoc citrovorum ; earlier in masculine form, as in the original name of the organism, Streptococcus citrovorus : B. W. Hammer 1920, in Res. Bull. Agric. Exper. Station Iowa 63 91; < citro- citro- comb. form + -vorus : see -vorous comb. form), so called on account of its ability to metabolize citric acid.

Biology and Medicine.

A substance required for the growth of the lactic acid bacterium Leuconostoc cremoris (formerly L. citrovorum), subsequently identified as folinic acid and used to modify or mitigate the effects of methotrexate and other chemotherapeutic agents. Chiefly attributive, esp. in citrovorum factor. Also called leucovorin.

ΚΠ

1948 H. E. Sauberlich & C. A. Baumann in Jrnl. Biol. Chem. 176 168 The ‘citrovorum unit’ was designated as the amount of substance required per ml. to give one-half maximal acid production in 72 hours by Leuconostoc citrovorum 8081.

1948 H. E. Sauberlich & C. A. Baumann in Jrnl. Biol. Chem. 176 171 The former [sample]..proved to be one of the most potent concentrates of the citrovorum factor thus far encountered.

1957 J. H. Burn Princ. Therapeutics xxi. 180 Folic acid is converted in the body into folinic acid, which is also known as the citrovorum factor.

1975 Daily Colonist (Victoria, Brit. Columbia) 25 Mar. 34/6 The..drug citrovorum..rescues the normal cells from death after the cancer cells are poisoned by methotrexate.

2009 I. Ayan et al. in N. Jaffe et al. Pediatric & Adolescent Osteosarcoma 332 Patients..were given high-dose methotrexate (12 g/m2/day) with citrovorum rescue every 2-3 weeks.

This entry has been updated (OED Third Edition, June 2014; most recently modified version published online March 2022).

单词	citrovorum
释义	citrovorumn. Brit. /sɪtrəˈvɔːrəm/, U.S. /ˌsɪtrəˈvɔrəm/ Origin: A borrowing from Latin. Etymon: Latin citrovorum. Etymology: < scientific Latin citrovorum, former specific epithet (1939 or earlier, in Leuconostoc citrovorum ; earlier in masculine form, as in the original name of the organism, Streptococcus citrovorus : B. W. Hammer 1920, in Res. Bull. Agric. Exper. Station Iowa 63 91; < citro- citro- comb. form + -vorus : see -vorous comb. form), so called on account of its ability to metabolize citric acid. Biology and Medicine. A substance required for the growth of the lactic acid bacterium Leuconostoc cremoris (formerly L. citrovorum), subsequently identified as folinic acid and used to modify or mitigate the effects of methotrexate and other chemotherapeutic agents. Chiefly attributive, esp. in citrovorum factor. Also called leucovorin. ΚΠ 1948 H. E. Sauberlich & C. A. Baumann in Jrnl. Biol. Chem. 176 168 The ‘citrovorum unit’ was designated as the amount of substance required per ml. to give one-half maximal acid production in 72 hours by Leuconostoc citrovorum 8081. 1948 H. E. Sauberlich & C. A. Baumann in Jrnl. Biol. Chem. 176 171 The former [sample]..proved to be one of the most potent concentrates of the citrovorum factor thus far encountered. 1957 J. H. Burn Princ. Therapeutics xxi. 180 Folic acid is converted in the body into folinic acid, which is also known as the citrovorum factor. 1975 Daily Colonist (Victoria, Brit. Columbia) 25 Mar. 34/6 The..drug citrovorum..rescues the normal cells from death after the cancer cells are poisoned by methotrexate. 2009 I. Ayan et al. in N. Jaffe et al. Pediatric & Adolescent Osteosarcoma 332 Patients..were given high-dose methotrexate (12 g/m2/day) with citrovorum rescue every 2-3 weeks. This entry has been updated (OED Third Edition, June 2014; most recently modified version published online March 2022). < n.1948
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