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单词 chloralamide
释义

chloralamiden.

/klɔːrəˈleɪmʌɪd/
Etymology: < German chloralamid, shortened form of chloralformamid : compare chloral n. and amide n.
A compound that results from a condensation reaction of chloral with an acid amide; spec. chloral formamide, CCl3·CH(OH)·NH· CHO, a mild hypnotic.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > hypnotic > specific drugs
codeine1833
codeia1834
chloral1838
paraldehyde1857
hypnone1886
chloralamide1889
sulphonal1889
uralium1889
ural1891
thymacetin1892
chloralose1893
chloretone1899
hedonal1900
veronal1903
Medinal1908
barbitone1914
barbital1919
Sedormid1928
benzodiazepine1934
hexobarbital1941
hexobarbitone1941
glutethimide1955
Placidyl1955
Mogadon1956
chlordiazepoxide1960
nitrazepam1965
flurazepam1968
medazepam1968
lorazepam1969
Rohypnol1971
flunitrazepam1973
triazolam1973
methapyrilene1974
Halcion1975
1889 Lancet 26 Oct. 849/2 The administration of 40 gr. of chloralamide the evening after gave him an unbroken sleep of nine hours.
1889 Lancet 7 Dec. 1192/1 Dr. Langaard of Berlin reviews in the Therapeutische Monatsschrift the present state of our knowledge of the action of chloralamide.
1897 Trans. Amer. Pediatric Soc. 9 168 The treatment consisted of the administration of nervous sedatives, at first chloralamide, to which later was added hyoscine.
1909 T. C. Allbutt & H. D. Rolleston Syst. Med. (ed. 2) VI. 490 I now use chloralamide which, I am told, is safer than chloral; it acts nearly as well.
1963 K. W. Wheeler in Campaigne & Hartung Med. Chem. VI. i. 12 The so-called chloralamides, products of the condensation of chloral with the NH2 of the amide, generally do have some hypnotic activity but not of a high order.
This entry has not yet been fully updated (first published 1933; most recently modified version published online December 2018).
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