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单词 cholestasis
释义

cholestasisn.

Brit. /ˌkəʊlᵻˈsteɪsɪs/, /ˌkɒlᵻˈsteɪsɪs/, U.S. /ˌkoʊləˈsteɪsɪs/
Origin: Formed within English, by compounding; partly modelled on a French lexical item, and partly modelled on a German lexical item. Etymons: chole- comb. form, stasis n.
Etymology: < chole- comb. form + stasis n., after French choléstase (1883 or earlier) and its model German Cholestasis (1860 or earlier).
Medicine.
Cessation or reduction of the flow of bile, typically resulting from obstruction within the larger bile ducts or gall bladder (more fully extrahepatic cholestasis) or from factors affecting bile secretion or flow within the liver (more fully intrahepatic cholestasis).
ΚΠ
1888 tr. A. J. d'Oliveira Castro Elements Therapeutics & Pract. Dosimetric Syst. 309 (table) Cholestasis.
1926 Lancet 2 Oct. 691/2 The second type, that of ‘cholestasis’, is met with in biliary passages of lower muscular tone with a weaker sphincter.
1952 H. Popper & F. Schaffner in Jrnl. Amer. Med. Assoc. 6 Dec. 1372/1 Intrahepatic cholestasis cannot be differentiated from extrahepatic cholestasis by laboratory tests.
1988 W. Friedrich Vitamins iv. 271 There are two forms of chronic cholestasis, the intrahepatic and the extrahepatic (the latter is also called biliary atresia).
2006 Guardian 13 June i. 32/5 He campaigned for better diagnosis of intrahepatic cholestasis of pregnancy, a condition that caused about half of all stillbirths.
This is a new entry (OED Third Edition, June 2014; most recently modified version published online March 2022).
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n.1888
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