transitive. To regard with malice; to bear malice towards; to seek or desire to injure.

With at (a person or thing). Obsolete.

To treat spitefully or maliciously; to annoy or thwart in a spiteful manner.

transitive. To behave like a bitch towards (a person); to be spiteful, malicious, or unfair to (a person); to let (a person) down.

to getor have one's knife into (a person): to exhibit a malicious or vindictive spirit towards; to persecute unrelentingly.