the world > action or operation > behaviour > customary or habitual mode of behaviour > unaccustomedness or state of disuse > give up a habit or practice [verb (transitive)] > cause one to or disaccustom > withdraw from usual activity > render remote from one's usual state (1)
To change, render remote from one's accustomed or normal condition; to make unlike oneself; hence, to put beside oneself, madden. Obsolete.