the world > action or operation > advantage > efficacy > [adjective] > greatly > in the utmost degree (6)
Strongest (see the senses of strong, adj.).
Of remedies, etc.: Efficacious or potent in a superlative degree. Frequently in figurative use.
Going to great lengths; opposed to moderate. Of material agents, influences, etc.: Effective in the utmost degree; exceedingly intense or…