To deprive of efficacy, force, or value; to render inoperative or meaningless; to set aside or nullify. Now rare.

transitive. In extended and figurative use. To destroy or inhibit the vitality, vigour, activity, or potency of; to neutralize the effect or…

to lay in water: to render inoperative, ineffective, or invalid; to cause to be nullified or wasted; to dissipate. In early use also to lay a water…

To deprive of effect, render ineffectual; to neutralize, counteract (an effort or effect).

? To deprive of force, make of none effect.

transitive. In extended use: to cut back or curtail so as to render ineffectual; to impose brutal or ruinous change on.

To check, retard (motion or force); to destroy the force or effect of (a missile, etc.).

transitive. To render ineffective.

transitive. To render ineffectual.

transitive. To render (a thing) ineffective or inoperative. rare in later use.