alkylatingn.

Brit.

/ˈalkᵻleɪtɪŋ/, U.S.

/ˈælkəˌleɪdɪŋ/

Origin: Formed within English, by derivation. Etymons: alkylate v., -ing suffix¹.

Etymology: < alkylate v. + -ing suffix¹. Compare earlier alkylation n.

Chemistry.

The action or process of alkylating a substance; alkylation.Sometimes not easily distinguishable from alkylating adj.

ΚΠ

1914 Jrnl. Industr. & Engin. Chem. 6 1021/1 Alkylating—This is the introduction of methyl or ethyl groups into hydroxyl groups or into amido groups.

1967 I. L. Finar Org. Chem. (ed. 5) I. xxv. 655 It is because of this alkylating action on alcohols that sulphonic esters cannot be prepared by direct esterification.

1967 Science 1 Dec. 1142/3 These and other ‘mustards’..act by alkylating of biologically important macromolecules.

2006 Analyt. Chem. 78 6583 The implementation of an alkylating step with iodoacetamide.

This entry has been updated (OED Third Edition, September 2009; most recently modified version published online December 2021).

alkylatingadj.

Brit.

/ˈalkᵻleɪtɪŋ/, U.S.

/ˈælkəˌleɪdɪŋ/

Origin: Formed within English, by derivation. Etymons: alkylate v., -ing suffix².

Etymology: < alkylate v. + -ing suffix².

Chemistry.

Of a substance, group, etc.: that alkylates other compounds or groups.Sometimes not easily distinguishable from alkylating n.Recorded earliest in alkylating agent n. at Compounds.

ΚΠ

1900 Jrnl. Chem. Soc. 78 i. 619 Dimethyl sulphate as an alkylating agent.

1915 Science 16 July 99/2 Its use as an alkylating reagent is very simple.

1968 New Eng. Jrnl. Med. 11 Jan. 95/1 In most clinics the first chemotherapeutic agents employed are the alkylating drugs, either nitrogen mustard itself or its derivatives chlorambucil and cyclophosphamide.

1990 Mutagenesis 5 531/1 While these compounds are acridines, they carry an alkylating (nitrogen mustard) substituent.

2002 Carcinogenesis 23 2081/2 Increasing levels of alkylating compounds such as tobacco-specific nitrosamines (TSNA) in cigarette smoke.

Compounds

alkylating agent n. a substance that brings about alkylation; (Pharmacology) any of a class of cytotoxic immunosuppressant drugs which alkylate DNA and are used in cancer chemotherapy.

ΚΠ

1900*Alkylating agent [see main sense].

1961 Lancet 29 July 250/1 Chemotherapy with various alkylating agents.

1989 Jrnl. Exper. Bot. 40 1016/1 Vacuum-distilled 4-vinylpyridine was used as the alkylating agent and the reaction was allowed to proceed overnight.

2003 Trinity Today Oct. 30/1 Temozolomide, a member of a class of anti-cancer drugs known as alkylating agents.

This entry has been updated (OED Third Edition, September 2009; most recently modified version published online December 2021).

单词	alkylating
释义	alkylatingn. Brit. /ˈalkᵻleɪtɪŋ/, U.S. /ˈælkəˌleɪdɪŋ/ Origin: Formed within English, by derivation. Etymons: alkylate v., -ing suffix¹. Etymology: < alkylate v. + -ing suffix¹. Compare earlier alkylation n. Chemistry. The action or process of alkylating a substance; alkylation.Sometimes not easily distinguishable from alkylating adj. ΚΠ 1914 Jrnl. Industr. & Engin. Chem. 6 1021/1 Alkylating—This is the introduction of methyl or ethyl groups into hydroxyl groups or into amido groups. 1967 I. L. Finar Org. Chem. (ed. 5) I. xxv. 655 It is because of this alkylating action on alcohols that sulphonic esters cannot be prepared by direct esterification. 1967 Science 1 Dec. 1142/3 These and other ‘mustards’..act by alkylating of biologically important macromolecules. 2006 Analyt. Chem. 78 6583 The implementation of an alkylating step with iodoacetamide. This entry has been updated (OED Third Edition, September 2009; most recently modified version published online December 2021). alkylatingadj. Brit. /ˈalkᵻleɪtɪŋ/, U.S. /ˈælkəˌleɪdɪŋ/ Origin: Formed within English, by derivation. Etymons: alkylate v., -ing suffix². Etymology: < alkylate v. + -ing suffix². Chemistry. Of a substance, group, etc.: that alkylates other compounds or groups.Sometimes not easily distinguishable from alkylating n.Recorded earliest in alkylating agent n. at Compounds. ΚΠ 1900 Jrnl. Chem. Soc. 78 i. 619 Dimethyl sulphate as an alkylating agent. 1915 Science 16 July 99/2 Its use as an alkylating reagent is very simple. 1968 New Eng. Jrnl. Med. 11 Jan. 95/1 In most clinics the first chemotherapeutic agents employed are the alkylating drugs, either nitrogen mustard itself or its derivatives chlorambucil and cyclophosphamide. 1990 Mutagenesis 5 531/1 While these compounds are acridines, they carry an alkylating (nitrogen mustard) substituent. 2002 Carcinogenesis 23 2081/2 Increasing levels of alkylating compounds such as tobacco-specific nitrosamines (TSNA) in cigarette smoke. Compounds alkylating agent n. a substance that brings about alkylation; (Pharmacology) any of a class of cytotoxic immunosuppressant drugs which alkylate DNA and are used in cancer chemotherapy. ΚΠ 1900Alkylating agent [see main sense]. 1961 Lancet* 29 July 250/1 Chemotherapy with various alkylating agents. 1989 Jrnl. Exper. Bot. 40 1016/1 Vacuum-distilled 4-vinylpyridine was used as the alkylating agent and the reaction was allowed to proceed overnight. 2003 Trinity Today Oct. 30/1 Temozolomide, a member of a class of anti-cancer drugs known as alkylating agents. This entry has been updated (OED Third Edition, September 2009; most recently modified version published online December 2021). < n.1914adj.1900
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