They published a paper suggesting that the potential of paracetamol as a pain reliever should be revisited.

It was also been suggested to be a general pain reliever and health improver.

By the 1970s, aspirin had a relatively small portion of the pain reliever market, and in the 1980s sales decreased even more when ibuprofen became available without prescription.

Is it true that pain relievers (such as ibuprofen) cause hearing loss?

Advances in medicine and public health played a role: acceptance of the germ theory of disease, vaccines, x-rays, and the debut of new pain relievers, such as aspirin in 1899.