The autoimmune response subsequently leads to the destruction of parietal cells, which leads to profound hypochlorhydria (and elevated gastrin levels).

Suggested theories include tumor production of plakin proteins which initiate an autoimmune response against them, and cross-reactivity of tumor antigens and epidermal antigens.

Exactly how altered regulatory thresholds allow the triggering of a specific autoimmune response remains uncertain.

This mutation would induce an autoimmune response and inhibit fertility.

The conjunctiva can become inflamed due to an infection or an autoimmune response.