This gap in healthy life expectancy between affluent older people and those on low incomes is a major cause for concern.

It suggested that diesel vehicles were a major cause.

We now know that smoking is a major cause of lung cancer, whereas pesticides are not.

UV rays are the biggest enemy in the fight against ageing and a major cause of wrinkles and age spots.

In transparent orthographies, persistent reading fluency difficulties are a major cause of poor reading skills in primary school.