These allowed for more control over food production than had ever been imagined possible, with worldchanging and irreversible consequences.

These are errors with irreversible consequences.

It recommends deferring all non-trivial surgeries which have irreversible consequences.

Have potential long-term and irreversible consequences been seriously evaluated, and by whom?

Of all those who tampered with time, she was the only one who seemed concerned that what they had done may have had irreversible consequences.