The fruit will not evolve resistance, because it cannot evolve.

The virus may also evolve resistance, further limiting their role.

Hosts continue to evolve resistance to parasites and parasites continue to bypass resistant mechanisms, continuously generating genetic variation.

If other species can be preserved for long enough, they may evolve resistance as well.

This suggests that plague reduced in impact over the following centuries not because it became less virulent, but because human beings evolved resistance.