Against ferocious opposition within his own party and despite considerable scepticism among his opponents, he carried it through.

For investors this kind of breathless prognostification raises as many concerns as opportunities, alongside considerable scepticism.

There was considerable scepticism from the psychotherapeutic community, however.

Admittedly, statistics of drinking habits should be read with considerable scepticism.

In 1926, he reported the isolation and crystallization of insulin, though this announcement was met with considerable scepticism and not generally accepted for many years.