In fact, these superflies looked eerily like long-lived flies of past works from other groups—except those flies had undergone lifestyle modifications (like caloric restriction), not genetic ones.

An alternative theory suggests that caloric restriction inhibits a molecular pathway that regulates energy utilisation.

Controlled laboratory and clinical studies on caloric restriction are not the only source of useful information.

This longevity increase may be due to a caloric restriction effect.

Next, the proponent determines the level of caloric restriction they wish to implement in their regular eating pattern.