Most serological tests would succeed only after a certain period of time past the symptom onset (usually a week).

A maculopapular rash may present 48 days post symptom onset and may be accompanied by an increase in fever.

In addition, dopamine pathway dysfunction has not been reliably shown to correlate with symptom onset or severity.

In severe cases, patients generally begin to deteriorate around three to five days after symptom onset.

Participants are treated with desmoteplase as an intravenous bolus dose of 90 g/kg within three to 9 hours after stroke symptom onset.