The failure of the negotiations marked a significant setback for the group.
Times, Sunday Times
United's players knew that this was a significant setback, not to mention a painful one.
Times, Sunday Times
His representatives are adamant that he will not be risked if it could result in a significant setback.
Times, Sunday Times
The return of direct rule would be seen as a significant setback for the peace process.
Times, Sunday Times
If he were to take the job, it would be a significant setback.
Times, Sunday Times