But the most significant alteration has been in my attitude.
Times, Sunday Times (2006)
The most significant alteration is the installation of a family kitchen, behind the library.
Times, Sunday Times (2007)
Conversely, no significant alteration of fatigability was observed.
Vincent Martin, Sébastien Ratel, Julien Siracusa, Pascale Le Ruyet, Isabelle Savary-Auzeloux, Lydie Combaret, Christelle Guillet, Dominique Dardevet 2013, 'Whey proteins are more efficient than casein in the recovery of muscle functional properties following a casting induced muscle atrophy.', PLoS ONE