Although this answer was probably an overstatement, it was an indicator of a severe deficiency.

Agranulocytosis implies a more severe deficiency than granulocytopenia.

The typical dose for severe deficiency can be up to 300 mg per day.

Approximately 1 in 4000 newborn infants has a severe deficiency of thyroid function, while even more have mild or partial degrees.

In severe deficiency, hospital admission may be required for nutritional support and detailed advice from dietitians.