1. A city of southeast Sicily, Italy, on the Ionian Sea south-southeast of Catania. Founded by colonists from Corinth in the eighth century BC, it reached the height of its power in the fifth century but fell to the Romans in 212.

2. A city of central New York east-southeast of Rochester. Established as an Onondagan trading post near a large salt deposit, it became a major saltworks in the 1800s and is now the site of Syracuse University.