n. pl. bo·lus·es 1. A round mass: "A dense bolus of trapped dolphins fills the frame" (Kenneth Browser).
2. a. A single, relatively large quantity of a substance, such as a dose of a drug, intended for therapeutic use and taken orally.
b. A concentrated mass of a substance administered intravenously for diagnostic or therapeutic purposes.
3. A soft mass of chewed food within the mouth or digestive tract.