1. also São Tia·go (souɴ tē-äg, tyäg) An island of southern Cape Verde in the northern Atlantic Ocean. It is the largest island in the group and the site of the capital, Praia.

2. The capital and largest city of Chile, in the central part of the country east-southeast of Valparaiso. On a plain in the foothills of the Andes, it was founded in 1541.

3. also Santiago de los Ca·bal·le·ros (dā′ lōs kä′bəl-yĕrōz, dĕ lōs kä′vä-yĕrōs) A city of northern Dominican Republic northwest of Santo Domingo. Settled c. 1500, it is a transportation hub in a fertile agricultural region.

4. also Santiago de Com·pos·te·la (də kŏm′pə-stĕlə, thĕ kōm′pōs-tĕlä) A city of northwest Spain south-southwest of La Coruña. The city grew around a shrine housing the reputed tomb of Saint James the Great (discovered in the ninth century) and has long been a pilgrimage center.