| 释义 |
statin, n.
Brit. |ˈstatɪn|, U.S. |ˈstæˌdɪn|
[‹ -statin (in somatostatin n., nystatin n., and other names of substances having inhibiting effects). Compare -stat comb. form, -in suffix1.]
1. Biochem. A phosphoprotein which is present in the nuclei of non-replicating or senescent cells, but not in cells that are undergoing replication.
1985E. Wang in Jrnl. Cell Biol. 1011695 (title) Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling. 1994Jrnl. Cell Physiol. 158277 (title) Characterization of 57 kDa statin as a true marker for growth arrest in tissue by its disappearance from regenerating liver. 1997Haemotologica 82 338 Blast cells from 15 patients with acute myeloid leukemia..were examined with two monoclonal antibodies that identify, respectively, the nuclear protein specifically expressed in non proliferating cells (statin) and the proliferating cell nuclear antigen (PCNA).
2. Pharmacol. Any of a class of cyclic organic compounds, chiefly lactones or pyrroles, that inhibit the synthesis of cholesterol in the liver, and are used in the treatment and management of high blood cholesterol levels.
1987Circulation 76 532/1 Lovastatin (formerly mevinolin) and synvinolin belong to the new group of statins, which lower serum cholesterol by stimulating removal of LDL via the LDL-receptor pathway. 1992Lancet 13 June 1488/1 ‘Statins’ (inhibitors of HMG CoA reductase) are very effective in adults with primary hypercholesterolaemia and side-effects are not frequent. 1998Esquire Mar. 136/1 If your LDL is over 130 and your HDL under 50, then you and your physician should at least consider these statin drugs. |