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单词 spironolactone
释义 spironolactone Pharm.|ˌspaɪərənəʊˈlæktəʊn|
[f. spirolactone.]
A steroid spirolactone derivative, C24H32O4S, which is an aldosterone antagonist, increasing sodium excretion, and is used esp. in the treatment of œdema and hypertension associated with hyperaldosteronism.
1960Austral. Ann. Med. IX. 188/1 In the present paper we describe the use of a similar drug, spironolactone (‘SC 9420’, ‘Aldactone’, Searle).1961Lancet 2 Sept. 528/2 Spironolactone 100 mg. four times daily definitely improved six out of seven myasthenic patients.1974R. M. Kirk et al. Surgery vii. 146 Treatment with diuretics or spironolactone, and dietary salt restriction, help to reduce the accumulation of fluid.1977Lancet 17 Sept. 600/2 Spironolactone relieved muscle fatigue in paramyotonia congenita—an effect possibly mediated by the accompanying hyperkalæmia.
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