| 释义 |
spirolactone Chem. and Pharm.|spaɪrəʊˈlæktəʊn|
[f. spiro- 2 + lactone 2.]
Any spirane in which one of the rings is a lactone; spec. any of the series of steroid derivatives to which spironolactone belongs.
1958Canad. Med. Assoc. Jrnl. LXXIX. 883/1 The administration of Spirolactone results in a persistent and significant increase in sodium excretion. 1959Jrnl. Org. Chem. XXIV. 743/1 The spirolactone side chain was built onto a steriod nucleus containing an aromatic A ring. 1961Lancet 16 Sept. 618/2 With the development of the 17-spirolactones, which are aldosterone antagonists, a new method has become available for investigating possible cases of primary aldosteronism. 1970Passmore & Robson Compan. Med. Stud. II. xi. 10/1 The main reason for believing that spirolactones are aldosterone antagonists is that they reverse all the renal effects of aldosterone. |