| 释义 |
COX, n.3 Biochem. and Med.
Brit. |kɒks|, U.S. |kɑks|
[‹ c- and -ox- (in cyclooxygenase n.).]
The enzyme cyclooxgenase. Freq. with distinguishing number designating its main forms: COX-1 n. a form producing prostaglandins involved in normal physiological processes including protection of the gastrointestinal mucosa. COX-2 n. a form producing prostaglandins involved in inflammatory and neoplastic processes.
1982Internat. Jrnl. Immunopharmacol. 4 351 Cyclooxygenase (COX) from sheep seminal vesicles. 1996New Scientist 30 Nov. 30/2 The drugs work by blocking the action of two enzymes, called cyclooxygenase 1 and 2 (COX-1 and COX-2). 2005G. Critzer Generation Rx i. 82 They are converted to those two functions by an enzyme system known as cyclooxygenase, COX.
Compounds. COX-2 inhibitor n. any of a subclass of non-steroidal anti-inflammatory drugs that selectively inhibit COX-2, thereby reducing some of the side-effects, esp. gastrointestinal irritation and bleeding, associated with earlier anti-inflammatory drugs.
1994Proc. Nat. Acad. Sci. U.S.A. 91 3228/1 Furthermore, NS-398, a selective *COX-2 inhibitor, and indomethacin, a nonselective COX-1 / COX-2 inhibitor, blocked proinflammatory PG synthesis in the air pouch. 1998Mt. Democrat (Placerville, Ca.) 30 Mar. a8/1 This drug is one of a brand new class of arthritis medications known as COX-2 inhibitors. 2004N.Y. Times 14 Nov. 1/2 The review..raises..questions about an entire class of..new painkillers called COX-2 inhibitors. |