| 释义 |
somatomedin Physiol.|ˌsəʊmətəʊˈmiːdɪn|
[See quot. 1972.]
Any of several peptides present in serum which are thought to act as intermediates in the stimulation of growth by growth hormone.
Quots. 1971, 1972 have no author in common.
1971J. M. Tanner et al. in Arch. Dis. Childhood XLVI. 761/2 A few patients with short stature have the ability to secrete immunoreactive GH..; but their GH fails to stimulate the production of somatomedin, a substance found in the blood, and previously named ‘sulphation factor’. 1972W. H. Daughaday et al. in Nature 14 Jan. 107/2 After consideration of many alternatives to the operational terms ‘sulphation factor’ or ‘thymidine factor’, we propose the more general term, ‘somatomedin’; the prefix, ‘somato’, connotes both a hormonal relationship to somatotropin and, also, to the soma which is the target tissue of this agent. ‘Medin’ is included in the name to indicate that it is an intermediary in somatotropin action. 1978Van Wyk & Underwood in G. Litwack Biochem. Actions Hormones V. iii. 102 It is..generally agreed that to belong in the somatomedin group of peptides, a substance must fulfil three criteria: its concentration in serum must be growth-hormone dependent, it must possess insulin-like actions in skeletal tissues, and it must promote the incorporation of sulfate into proteoglycans of cartilage. 1978F. L. Strand Physiology xix. 360/1 Growth hormone, the somatomedins, insulin, and thyroxine have important anabolic effects that promote wound healing. |